Community Resilience Assessment and Identification of Barriers in the Context of Population Aging: A Case Study of Changchun City, China

As a susceptible demographic, elderly individuals are more prone to risks during sudden disasters. With the exacerbation of aging, new challenges arise for urban disaster reduction and prevention. To address this, the key is to establish a community-scale resilience assessment framework based on the aging background and to summarize factors that influence the resilience level of communities. This approach is a crucial step towards seeking urban disaster prevention and reduction from the bottom up, and serves as an important link to enhance the capacity of urban disaster reduction. This paper explores community resilience evaluation indicators under the background of aging, builds a community resilience evaluation index system based on the Pressure–State–Response, uses the entropy weight method to weigh the indicators, and carries out a resilience evaluation of 507 communities in the main urban area of Changchun. The empirical results indicate significant spatial differentiation of community resilience in the main urban area of Changchun. Moreover, the regional development is unbalanced, showing a spatial distribution pattern of weakness in the middle and strength in the periphery. The ring road network highlights the difference between the new and old urban areas. The high contribution indexes of community resilience in the main urban area of Changchun were concentrated on disaster relief materials input, community self-rescue ability, and disaster cognition ability. Finally, strategies to improve community resilience are proposed from the perspectives of stress, state, and response, emphasizing community residents' participation, conducting disaster prevention and reduction training, and improving community response-ability.

Effects of coronavirus disease 2019 vaccination on seizures in patients with epilepsy.

BACKGROUND: Given that seizures may be triggered by vaccination, this study aimed to evaluate the risk and correlative factors of seizures in patients with epilepsy (PWE) after being vaccinated against coronavirus disease 2019 (COVID-19). METHODS: This study retrospectively enrolled PWE who were vaccinated against COVID-19 in the epilepsy centers of 11 hospitals in China. We divided the PWE into two groups as follows: (1) patients who developed seizures within 14 days of vaccination were assigned to the SAV (with seizures after vaccination) group; (2) patients who were seizure-free within 14 days of vaccination were assigned to the SFAV (seizure-free after vaccination) group. To identify potential risk factors for seizure reccurence, the binary logistic regression analysis was performed. Besides, 67 PWE who had not been vaccinated were also included for elucidating the effects of vaccination on seizures recurrence, and binary logistic regression analysis was performed to determine whether vaccination would affect the recurrence rate of PWE who had drug reduction or withdrawal. RESULTS: The study included a total of 407 patients; of which, 48 (11.8%) developed seizures within 14 days after vaccination (SAV group), whereas 359 (88.2%) remained seizure-free (SFAV group). The binary logistic regression analysis revealed that duration of seizure freedom ( P  < 0.001) and withdrawal from anti-seizure medications (ASMs) or reduction in their dosage during the peri-vaccination period were significantly associated with the recurrence of seizures (odds ratio = 7.384, 95% confidence interval = 1.732-31.488, P  = 0.007). In addition, 32 of 33 patients (97.0%) who were seizure-free for more than three months before vaccination and had a normal electroencephalogram before vaccination did not have any seizures within 14 days of vaccination. A total of 92 (22.6%) patients experienced non-epileptic adverse reactions after vaccination. Binary logistic regression analysis results showed that vaccine did not significantly affect the recurrence rate of PWE who had the behavior of ASMs dose reduction or withdrawal ( P  = 0.143). CONCLUSIONS: PWE need protection from the COVID-19 vaccine. PWE who are seizure-free for >3 months before vaccination should be vaccinated. Whether the remaining PWE should be vaccinated depends on the local prevalence of COVID-19. Finally, PWE should avoid discontinuing ASMs or reducing their dosage during the peri-vaccination period.

In Silico Studies, Biological Activities, and Anti-human Pancreatic Cancer Potential of 6-Hydroxy-4-methylcoumarin and 2,5-Dihydroxyacetophenone as Flavonoid Compounds.

Coronavirus is one of the RNA viruses with the largest genome; It is a group of viruses known to infect humans very little until the end of the 20th century, generally causing infection in animals (bird, cat, pig, mouse, horse, bat). It is the causative agent of 15-30% of seasonal lower and upper respiratory tract infections, and may rarely cause gastrointestinal and nervous system infections. We have obtained results for the collagenase and elastase enzymes were at the micromolar level. We obtained IC50 results for the collagenase enzyme for 6-hydroxy-4-methylcoumarin 257.22 ± 34.07 µM and for 2,5-dihydroxyacetophenone 74.46 ± 8.61 µM. 6-Hydroxy-4-methylcoumarin and 2,5-dihydroxyacetophenone were considered good inhibitors for elastase enzyme. Additionally, these compounds significantly decreased human pancreatic cancer cell viability from low doses. In addition, 100 µM dose of all compounds caused significant reductions in human pancreatic cancer cell viability. IC50 results (IC50: 10-50 µM) were better than control. In the otherwords, the docking results suggest that both compounds tend to have lower efficacy on the main protease targets of SARS-CoV-2 than standard compounds, (NL-1 and NL-2). The reason for this is that the standard compounds interact strongly and more frequently with the target proteins, and the surface areas they cover on the active surface are much larger than the small ligand molecules studied.

Detections of major respiratory pathogens in pneumonia patients in early phase of COVID-19 epidemic in Tongzhou, Beijing

Objective: To understand the infection status of major respiratory pathogens in pneumonia patients in the early phase of coronavirus disease 2019 (COVID-19) epidemic (January-March, 2020) in Tongzhou district of Beijing.

Vision of China's future urban construction reform: In the perspective of comprehensive prevention and control for multi disasters.

The COVID-19 pandemic has caused huge deaths, massive damage and losses around the world. Looking back in history, the motivation for construction and development of cities was to enhance disaster prevention capacity, while modern cities are built and developed to improve health and wellness for human beings. Each disaster would pose some new challenges to the urban planning and architectural design, such as COVID-19. Therefore, the dilemma of future multi disasters (e.g. epidemics) would lead to reflections on the revision or change of urban design regulations. For the post-epidemic era, a comprehensive and integrated prevention system should be established for multi urban disasters, which requires to be optimally formulated based on multiple objectives, i.e., on the balancing of disaster occurrence probability and stop loss cost. This will be realized thanks to the rapid development of digital alike advanced technologies. Thus, this paper aims to provide a reference for the prevention and control of future city epidemics and disasters in responding to strategies of urban planning and design by considering the reform of urban construction related regulations, further to facilitate the creation of healthy and safe urban environments.